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Buy Isopropylphenidate ( IPH IPPD) crystal

Buy Isopropylphenidate ( IPH IPPD) crystal. Isopropylphenidate (also known as IPH and IPPD) is a piperidine based, stimulant drug closely related to methylphenidate, but with the methyl ester replaced by an isopropyl ester. It has similar effects to methylphenidate but with a longer duration of action,and was banned in the UK as a Temporary Class Drug from April 2015 following its unapproved sale as a designer drug.
It has been researched as potential methylphenidate replacement for ADHD and narcolepsy, because of fewer side effects. Buy Isopropylphenidate ( IPH IPPD) crystal Buy Isopropylphenidate ( IPH IPPD) crystal

Isopropylphenidate Crystal (also known as IPH, IPPH, and IPPD) is synthetic stimulant of the phenidate chemical class . It is a structural analog of the widely-prescribed ADHD medication methylphenidate. Buy Isopropylphenidate ( IPH IPPD) crystal Buy Isopropylphenidate ( IPH IPPD) crystal

Isopropylphenidate for sale has been investigated for its potential use as a replacement for methylphenidate in the treatment of ADHD and related disorders. One study found that it displayed the same basic activity as a norepinephrine-dopamine reuptake inhibitor (NDRI), possessing, along with both methylphenidate and ethylphenidate, an appreciably high affinity for the dopamine transporter and effects on its cellular reuptake. It displayed comparably minor effects on norepinephrine, however, which was theorized to mean it may possess a more desirable safety and toxicity profile. Learn More

Chemistry Isopropylphenidate

buy Isopropylphenidate is a synthetic molecule of the substituted phenethylamine and phenidate classes. It contains a phenethylamine core featuring a phenyl ring bound to an amino (NH2) group via an ethyl chain. It is structurally similar to amphetamine, featuring a substitution at Rα which is then incorporated into a piperidine ring ending at the terminal amine of the phenethylamine chain. Additionally, it contains an isopropyl acetate bound to Rβ of its molecular structure, a noticeable departure from methylphenidate, which contains a methyl group in this position. Buy Isopropylphenidate ( IPH IPPD) crystal
Isopropylphenidate structurally diverges from ethylphenidate and methylphenidate by the length of the carbon chain on their acetate group. Iso- regards the side chain of one carbon atom branching into two bound methyl groups, phen- indicates the phenyl ring, id- is contracted from the piperidine ring, and -ate indicates the acetate group. Isopropylphenidate is a chiral compound, and has been documented as being produced as a racemic mixture and exclusively as either of its enantiomers. Learn More Buy Isopropylphenidate ( IPH IPPD) crystal

Isopropylphenidate Crystal Pharmacology

No formal in vivo human studies carried out using isopropylphenidate; however in vivo rat studies and in vitro studies have been performed to observe the stimulatory effects in rats, and evaluate the monoamine transporter binding affinities and affinities for various hydrolytic enzymes respectively. The results of these studies suggest that isopropylphenidate has a very similar pharmacology to its parent compound methylphenidate, with the notable differences between the two substances being isopropylphenidate displaying significantly less activity as a norepinephrine reuptake inhibitor and the CES1 hydrolytic enzyme, which is exclusively responsible for hydrolysing both substances to ritalinic acid, having an 8 times lower affinity for isopropylphenidate compared to methylphenidate. Buy Isopropylphenidate ( IPH IPPD) crystal

These differences result in the substance having more notable dopaminergic activity than adrenergic activity compared to methylphenidate at equivalent effective dosages, and in the substance having a longer duration than methylphenidate and a greater potency than methylphenidate at a given dosage. The greater potency of isopropylphenidate compared to methylphenidate is most significant with oral administration as the difference in potency is a result of the lower affinity of CES1 increasing the bioavailability of isopropylphenidate compared to methylphenidate, which is notably low for methylphenidate when administered orally due to first-pass metabolism in the liver by CES1. Buy Isopropylphenidate ( IPH IPPD) crystal

Despite the notable differences between the two substances, isopropylphenidate is still thought to act primarily as both a dopamine reuptake inhibitor and a norepinephrine reuptake inhibitor, meaning that it effectively boosts the levels of the norepinephrine and dopamine neurotransmitters in the brain by binding to and partially blocking the transporter proteins that normally remove those monoamines from the synaptic cleft. This allows dopamine and norepinephrine to accumulate within the brain, resulting in stimulatory effects. Buy Isopropylphenidate ( IPH IPPD)
  • 3,4-Dichloromethylphenidate, Ethylphenidate, Desoxypipradrol, HDEP-28, HDMP-28
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